微波與離子液體協同催化高效合成1,4-二氫吡啶類化合物

Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids

摘要: 在以吡啶為母體的離子液體和微波輻射協同催化下，以醋酸銨、間硝基苯甲醛和3-氧代-N-苯基丁酰胺為原料，通過Hantzsch反應一鍋合成2,6-二甲基-4-3ˊ-硝基苯基-N³,N⁵-二苯基-3,5-二甲酰胺-1,4-二氫吡啶化合物，產物結構通過¹H-NMR表征進行了確認。與文獻中描述的方法相比，該方法具有反應過程簡單、反應時間短、收率高、催化劑易重復使用等優點。

Abstract: 2,6-dimethyl-4-3ˊ-nitrophenyl-N³,N⁵-diphenyl-3,5-diformamide dihydropyridine was synthesized from 3-nitrobenzaldehyde, 3-oxygen-N-phenylbutanamide and ammonium acetate via Hantzsch reaction in the presence of ionic liquid with pyridine as the mother under microwave irradiation. The corresponding structure of the product is characterized by ¹H-NMR. Compared by the methods in the literature, this method has a simple reaction process, short reaction time, high yield, and easy reuse.